Xenobiotics in Chemical Carcinogenesis

Xenobiotics in Chemical Carcinogenesis covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in human body. The book begins with a historical review and linking it to the future prospective of chemical carcinogenesis. The book discusses major environmental xenobiotics and their risks in inducing cancer. The book goes on to discuss toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development. Lastly, Xenobiotics in Chemical Carcinogenesis explores current achievements like using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, development of anticancer drugs for specific toxicants. Covers the exposure and transmission of various toxic xenobiotics substances, including nanomaterials, to humans and their interaction with specific tissues in precipitating the development of cancers Unravels the toxicokinetic and toxicodynamic processes of toxic xenobiotics in bioaccumulation Examines the genetic aberrations in cancer genomes by genetic-environmental interactions in carcinogenesis Explains the biotransformation mechanisms of toxic xenobiotics by gut microbes in humans