Kontakt
Wie einkaufen
Versand
Kaufberater
Role of Neck and Hinge for the Mechanism of Conventional Kinesins
Englisch
151 b
Bis zu 30 Tage Rückgaberecht
Kunden kauften auch
/
Broschur
14.99
€
Conventional kinesins are molecular motors that walk along microtubules to carry out a large variety of cellular transport processes. The conventional kinesin of the filamentous fungus Neurospora crassa is 3-4 times faster than its animal relatives. Its neck domain displays characteristic properties that is also reflected in a specific sequence pattern. In the present work the functional roles of the specific neck and hinge domains for mechano-chemistry, dimerization and regulation of fast fungal kinesins are investigated. To address this issue, mutant protein constructs were generated, and characterized in terms of oligomerization, motility and kinetic properties. The results show that the specific neck and hinge regions are not critical for the basic mechanism of fast fungal kinesins. However, they play an important role for the regulation of the motor in a dimerization-based mechanism. In addition, the specific neck sequences may have evolved to fine-tune kinesin s processivity by combining tight structural connection of the head domains with a flexible tether that facilitates the diffusive search for the next microtubule binding site.
Informationen zum Buch
Englisch
Verschenken Sie dieses Buch noch heute
Es ist ganz einfach
1 Legen Sie das Buch in Ihren Warenkorb und wählen Sie den Versand als Geschenk 2 Wir schicken Ihnen umgehend einen Gutschein 3 Das Buch wird an die Adresse des beschenkten Empfängers geliefertDas könnte Sie auch interessieren
/
Broschur
18.10
€
/
Hardcover
30.60
€
/
Hardcover
39.61
€
/
Broschur
68.19
€
Hallo! Ich bin Libroamiko, dein Buchberater.
Wie kann ich dir helfen?