The Local Effect of Calcitonin and Alendronate on Osseous defects

Background: Bone regeneration is an important objective in clinical dental practice and has been used for different applications. The anabolic action of antiresorpative agent to promote bone formation and prevent further bone loss is a theoretically attractive approach for restoring bone mass. The ability of Alendronate and salmon Calcitonin to affect bone osteogenesis when employed systematically raises natural questions, if the local influence of both drugs could improve bone regeneration in controlled animal model. Aims of the Study: It was undertaken to evaluate the efficacy of locally applied ALO and sCT in surgically created bone defects in tibia of sheep by means of biochemical, radiographical, densitometric analysis, and histological evaluation of bone defects. Results: Serum Osteocalcin and Bone specific alkaline phosphatase revealed a tendency to increase in experimental groups when compared to control group. Radiographical image, bone density and histological analysis revealed significant acceleration of bone healing with increase in amount of bone formation and maturation of both tested groups over control group at 4th and 8th weeks with superiority to Alendronate.