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Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Therapeutic Implications, Volume 169 in the Advances in Immunology series, presents an authoritative exploration of how microbial communities contribute to the initiation, progression, and treatment of head and neck cancers. This volume examines the composition and dynamics of the head and neck microbiome, key factors driving dysbiosis, and mechanistic links to oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC). Chapters highlight emerging microbial biomarkers for early detection, the prognostic value of microbiome profiles, and innovative diagnostic and therapeutic approaches, including microbiome modulation and AI-based data analysis. Together, these insights provide clinicians, immunologists, oncologists, and cancer researchers with a comprehensive resource on the immunological and microbial interplay underlying head and neck malignancies.