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This book offers essential insights into the various roles and potential applications of phenazines, a group of nitrogen-containing redox-active heterocyclic compounds of bacterial origin. Phenazines have demonstrated a high degree of variability and are best known for their antibiotic properties, affecting a broad spectrum of organisms ranging from bacteria and fungi to plants, nematodes, parasites, and humans, which are discussed in several chapters. Topics also include the clinical anticancer use of phenazines, their role in biofilms associated with human infectious diseases and in the biological control of pseudomonads, as well as the diversity of habitats from which phenazine-producing microorganisms have been recovered. Further chapters describe the genomic features and regulation of phenazine biosynthesis, their biochemistry and physiological effects, the structural features of both natural and synthetic phenazines, as well as methods for isolating and identifying phenazines with the help of different spectroscopic and electrophoretic techniques.§
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