Kontakt
Wie einkaufen
Versand
Kaufberater
Formulation of Glibenclamide Solid dispersion
Englisch
125 b
Bis zu 30 Tage Rückgaberecht
Kunden kauften auch
In present work attempts have been made to formulate solid dispersion of Glibenclamide, by PEG 6000 and PVP K30. which is used as Antidiabetic agent in case of type II diabetes. Solid dispersion were prepared using polymer with PEG 6000 and PVP K30 in different ratio (1:1, 1:5, 1:10) by physical mixture, co-evaporation and melting method. In-vitro dissolution were carried out by keep in the phosphate buffer (pH 7.2) at interval of 4 hr for solid dispersion of different ratio (i.e. 1:1, 1:5, 1:10) & three different methods and results were good dissolution for solid dispersion by co-evaporation, method (CE 1:10) found to be (97.14%). The compatibility evaluations were performed by FTIR spectroscopy and DSC analysis. Both studies implies that the drug and polymers are compatible with each other. Assay were carried out for finally selected solid dispersion and the result were found to be 99.04% by UV Spectrophotometer. Stability studies were carried out by keeping the solid dispersion (CE 1:10) at room temperature and at a 40o C + 2oC / 75 + 5% RH (stability chambers) for 90 days results showing no change in physical appearance and invitro dissolution profile.
Informationen zum Buch
Englisch
Kategorie
Verschenken Sie dieses Buch noch heute
Es ist ganz einfach
1 Legen Sie das Buch in Ihren Warenkorb und wählen Sie den Versand als Geschenk 2 Wir schicken Ihnen umgehend einen Gutschein 3 Das Buch wird an die Adresse des beschenkten Empfängers geliefertDas könnte Sie auch interessieren
/
Broschur
22.79
€
/
Broschur
7.99
€
/
Broschur
19.19
€
/
Broschur
11.09
€
Hallo! Ich bin Libroamiko, dein Buchberater.
Wie kann ich dir helfen?