Clinical Cancer Genetics - Risk Counseling and Management

Ein wichtiger und umfassender Leitfaden für Präventivmediziner, die sich mit der genetischen Analyse von Krebspatienten oder potentiellen Risikopatienten für häufige Krebsarten beschäftigen. Es werden entscheidende Konzepte aus den Bereichen der Epidemiologie und Sozialwissenschaften eingeführt, um so einen integrierten Ansatz für jeden individuellen Fall zu ermöglichen. Dieses Werk ist von unschätzbarem Wert für die Beratung von Patienten, Familien und Kollegen hinsichtlich Verfügbarkeit, Nutzen und Grenzen der neuen Technik der genetischen Risikoanalyse. Ferner werden kommerzielle DNA Tests zur Bestimmung der familiär bedingten Veranlagung für mögliche Krebserkrankungen sowie deren soziale und ethische Aspekte näher betrachtet. (12/97)With a Foreword by Richard D. Klausner, M.D., Director, National Cancer Institute and an Introduction by Henry T. Lynch, M.D., President, Hereditary Cancer Institute and Director, Creighton Cancer Center, Creighton University.§When ordering a genetic test to determine whether a patient is susceptible to genetically transmitted cancers, physicians must be prepared to cope with profound medical, psychological, and ethical consequences. They, along with genetic counselors, nurses, psychologists, and other health professionals, must ensure that interpretations of test results are accurate, risk assessments are appropriate, and the communication of risk information is clear, helpful, and productive.§Clinical Cancer Genetics: Risk Counseling and Management is a comprehensive practical guide for health professionals responding to the growing demand for clinical cancer genetic services. Using examples drawn from actual cases and emphasizing fundamental principles throughout, this book outlines the scope of clinical cancer genetics and its underlying scientific concepts, reviews the most prevalent syndromes of cancer predisposition, and addresses major issues associated with genetic testing, including:§Use of quantitative methods in risk counseling§Methodologies of genetic testing§Genetic testing of patients with cancer§Reproductive risk counseling of cancer patients§Special psychological, ethical, and legal challenges in clinical cancer genetics§Supplemented with practical materials used in cancer genetic counseling programs and an annotated table of selected human cancer predisposition syndromes, Clinical Cancer Genetics: Risk Counseling and Management equips health care professionals with a complete understanding of the benefits and limitations of genetic testing technologies and the ability to integrate genetic information into the management of patients who are at risk or already affected by cancer.