Cellular Senescence

Cellular Senescence: Mechanisms, Disease Links, and Therapeutic Opportunities provides a comprehensive resource on cellular senescence and its significance as a fundamental driver of various diseases. This reference consolidates mechanistic insights and clinical relevance, bridging the gap between basic science and translational relevance to explore both the molecular underpinnings of senescence, and its implications for therapeutic innovation, highlighting how targeting senescent cells may reshape the future of medicine. The book systematically covers foundational concepts including senescence triggers, molecular pathways, and detection methods, progressing through disease-specific chapters on cancer, metabolic disorders, liver diseases, fibrosis, cardiovascular disease, neurodegenerative conditions and chronic inflammation. It highlights the paradoxical roles of senescent cells alongside emerging therapeutic strategies such as senolytics and senomorphics. Each chapter integrates current research, clinical insights, and translational applications. Step-by-step procedures, case studies, and learning objectives are also included throughout to aid understanding.

Cellular Senescence: Mechanisms, Disease Links, and Therapeutic Opportunities enhances understanding of the complex biology underlying this key cellular process. It is an ideal resource for cell biologists, biomedical researchers, clinicians, and graduate students in related areas who are looking to advance their understanding of cellular senescence and how it may be harnessed to treat a variety of diseases.

• Provides insight into how senescence can be modulated therapeutically, highlighting senolytics and senomorphics
• Investigates how cellular senescence contributes to disease initiation, progression, and treatment resistance
• Includes summary boxes and key takeaways to reinforce core concepts and support quick understanding
• Bridges multidisciplinary insights from oncology, aging, metabolism, and regenerative medicine for translational relevance